Touch not only conveys discriminative and affective information 1, but also can modulate cognition and emotional responses 2, 3. The sense of touch is fundamental for object recognition, motor control, and social communication in different mammalian species, including rodents and humans. Our findings demonstrate that enriched tactile experience retunes the pathway from S1 to DG and enhances DG neuronal plasticity to modulate cognition and emotion. Moreover, adulthood tactile enrichment attenuates early-life stress-induced memory deficits and anxiety-related behavior. Chemogenetic activation of tactile experience-tagged dorsal and ventral DG neurons enhances memory and reduces anxiety respectively, whereas inactivation of these neurons or S1-innervated LEC neurons abolishes the beneficial effects of tactile enrichment. Tactile enrichment induces differential activation and structural modification of neurons in the dorsal and ventral DG, and increases the presynaptic input from the lateral entorhinal cortex (LEC), which is reciprocally connected with the primary somatosensory cortex (S1), to tactile experience-activated DG neurons.
Here, we report that tactile experience enrichment improves memory and alleviates anxiety by remodeling neurons along the dorsoventral axis of the dentate gyrus (DG) in adult mice.
And then Attach accept.Touch can positively influence cognition and emotion, but the underlying mechanisms remain unclear. If UE sens the Initial Context Setup Response. To create a session success response, MME sends an Initial Context setup request with the GTP-U plane address of SGW along with other parameters. MME sends a create session request to the SGW over the S11 interface. MME sends the authentication request to the UE. Same time MME also does the Update Location procedures for subscriber information. MME does a send authentication info procedure with the HSS/AuC for authentication vectors. When UE switches on, it sends an Initial UE message with Attach request for PDN connectivity to the MME. Here we will describe a basic attach procedure to understand the basic functionality of the MME in LTE. Till now we have described key Interfaces of MME. The T6a interface is a diameter protocol interface with the SCEF for the Non-IP data delivery in the IoT network. The HSS may be co-located with the AUC for the 4G authentication. HSS is the node that holds the subscription data for a subscriber.
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